KLF4及MMP2在膀胱癌组织中的表达及相互关系

目的研究Krüppel样因子4(Krüppel-like factor 4,KLF4)及基质金属蛋白酶2(Matrix metalloproteinase 2,MMP2)在膀胱癌组织内的表达,分析两者间的相互关系,并探讨其可能机制及临床意义。方法收集2012年1月～2014年12月间115例膀胱癌患者的临床资料及肿瘤特征,采用免疫组化法检测膀胱癌组织内KLF4及MMP2的表达,分析两者之间的关系。结果 KLF4在膀胱癌组织中表达显著降低,与患者年龄、肿瘤浸润深度、组织学类型、淋巴结转移显著相关,与性别、肿瘤大小、数目无关。进一步分析发现KLF4及MMP2在癌组织中的表达存在显著负相关。结论 KLF4的低表达与膀胱癌的侵袭性增强密切相关,KLF4可能通过MMP2通路抑制了膀胱癌的侵袭性。

Expression and correlation of KLF4 and MMP2 in bladder cancer tissues

Objective To investigate the expression of Krüppel-like factor 4(KLF4)and matrix metalloproteinase 2(MMP2)in bladder cancer tissues,to analyze the correlations between the two,and to explore its possible mechanism and clinical significance.Methods The clinical data and tumor characteristics of 115 bladder cancer patients from January 2012 to December 2014 were collected.Immunohistochemistry was used to detect the expression of KLF4 and MMP2 in bladder cancer tissues.The correlations between the two were analyzed.Results The expression of KLF4 was significantly lower in bladder cancer tissues,significantly correlated with patient''s age,tumor invasion depth,histological type,and lymph node metastasis,but not correlated with gender,tumor size and number.Further analysis found that there was significant negative correlation between the expression of KLF4 and MMP2 in cancer tissues.Conclusion The low expression of KLF4 is closely correlated to the enhanced invasiveness of bladder cancer.KLF4 may inhibit the invasiveness of bladder cancer through the MMP2 pathway.