CYP2C19基因多态性及与其代谢相关药物的研究 |
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引用本文: | 徐晓晨,刘跃辉,塔,娜,黎雨珊,张东威▲.CYP2C19基因多态性及与其代谢相关药物的研究[J].中国现代医生,2018,56(1):165-168. |
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作者姓名: | 徐晓晨 刘跃辉 塔 娜 黎雨珊 张东威▲ |
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作者单位: | 内蒙古民族大学附属医院神经内科 |
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基金项目: | 内蒙古自治区自然科学基金项目(2015MS0882);内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目(201301075);内蒙古自治区高等学校科学研究项目(NJZY14190) |
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摘 要: | 细胞色素P450酶系(CYP450)是人体内参与药物代谢的主要酶,CYP2C19是细胞色素P450酶系中的一种。临床上多种药物在体内代谢时,均需要CYP2C19酶的参与。许多研究显示,CYP2C19酶的活性受CYP2C19基因多态性的影响。本文就CYP2C19基因多态性及其在体内参与几种药物的代谢情况进行分析与总结。
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关 键 词: | CYP2C19基因多态性 药物代谢 氯吡格雷 质子泵抑制剂 |
Study on CYP2C19 gene polymorphism and its metabolism-related drugs |
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Authors: | XU Xiaochen LIU Yuehui TA Na LI Yushan ZHANG Dongwei |
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Institution: | Department of Neurology,Affiliated Hospital of Inner Mongolia University for the Nationalities,Tongliao 028000,China |
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Abstract: | Cytochrome P450 enzyme system(CYP450)is the main enzyme involved in drug metabolism in the human body,and CYP2C19 is one of the cytochrome P450 enzymes.Clinically,when a variety of drugs are involved in vivo metabolism,they need the participation of CYP2C19 enzyme.Many studies have shown that the activity of CYP2C19 enzyme is affected by the CYP2C19 gene polymorphism.This article analyzes and summarizes the CYP2C19 gene polymorphism and its metabolic profile in several drugs in vivo. |
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Keywords: | CYP2C10 gene polymorphism Drug metabolism Clopidogrel Proton pump inhibitor |
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