舒肝凉血汤改善乳腺癌术后使用药物去势患者围绝经期综合征的临床研究

目的观察舒肝凉血汤改善乳腺癌术后使用药物去势患者围绝经期综合征的临床疗效。方法选取2015年6月～2017年10月在浙江省人民医院接受药物去势治疗出现围绝经期症状并经中医辨证为肝郁血热型的乳腺癌患者96例作为研究对象,采用随机双盲对照法分为治疗组和对照组,每组48例。治疗组给予内分泌治疗并服用舒肝凉血汤,对照组给予内分泌治疗并服用安慰剂,比较两组围绝经期症状变化情况及不良反应情况,并进行统计分析。结果治疗后,治疗组Kupperman评分下降近50%,40例治疗有效,总有效率为83.3%;对照组Kupperman评分下降不到27%,19例治疗有效,总有效率仅为39.6%,治疗组疗效显著优于对照组,差异有统计学意义(P0.05),两组均未发生明显不良反应。结论舒肝凉血汤能有效缓解乳腺癌术后使用药物去势患者的围绝经期症状,疗效安全可靠,值得临床推广应用。

Clinical study on Shugan Liangxue decoction in improving perimenopausal syndrome in the patients with breast cancer using postoperative medical castration

Objective To observe the clinical efficacy of Shugan Liangxue decoction in improving peri-menopausal syndrome in the patients with breast cancer using postoperative medical castration.Methods 96 cases with breast cancer receiving medical castration who developed peri-menopausal symptoms and who were diagnosed as having liver stagnation and blood heat by TCM differentiation during the period from June 2015 to October 2017 were selected.They were randomly divided into treatment group and control group with 48 cases in each group.The treatment group was treated with endocrine therapy and Shugan Liangxue decoction,while the control group was treated with endocrine therapy and placebo.The changes of peri-menopausal symptoms and adverse reactions were compared between the two groups,and statistical analysis was performed.Results After treatment,the Kupperman score in the treatment group decreased nearly 50%,40 cases were effective,and the total effective rate was 83.3%.the Kupperman score in the control group decreased less than 27%,19 cases were effective,and the total effective rate was only 39.6%.The curative effect in the treatment group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).There was no obvious adverse reaction in two groups.Conclusion Shugan Liangxue Decoction can effectively alleviate the peri-menopausal symptoms of patients with breast cancer receiving postoperative medical castration.The curative effect is safe and reliable,and it is worthy of clinical promotion and application.