凝血变化在SLE患者肾损害中的意义

目的探讨系统性红斑狼疮（SLE）患者肾损害时凝血指标的变化及意义。方法选取54例SLE患者为观察组，其中分为肾损害组29例，非肾损害组25例；检测血浆D-二聚体（D—Dimer,D—D）、纤维蛋白原降解产物（FDP）、血管性假性血友病因子抗原（VWF：Ag）、凝血酶调节蛋白（TM）、组织型纤溶酶激活物（t—PA）、纤维蛋白原（FIB）和血浆凝血酶原时间（P11）、活化部分凝血活酶时间（APTF）、凝血酶时间（1Tr）的水平，并作对比分析。结果SLE组D—D、VWF-Ag、TM和t-PA明显高于对照组（P〈0．01）；肾损害组上述四项指标明显高于非肾损害组（P〈0．01）；与对照组比较，PT、Am明显缩短（P〈0．01）；TT和FIB两项指标无统计学意义（P〉0．05）。结论D—D、VWF：Ag、TM、FDP和t—PA的水平变化与系统性红斑狼疮患者的肾损害明显关联，指标水平随着肾损害的加重而升高。

Coagulative index changes in kidney damage in patients with SLE

Objective To investigate the changes and significance of coagulative indexs of kidney damage in patients with systemic lupus erythematosus （SLE）. Methods A total of 54 patients with SLE in the observation group, the group of 29 cases of kidney damage, kidney damage group of 25 patients; plasma D-dimer （D-Dimer, D-D）, fibrinogen degra- dation product （FDP）, vascularvon Willebrand factor antigen （VWF： Ag）, thrombomodulin （TM）, tissue-type plasminogen activator （t-PA）, fibrinogen （FIB）, and the levels of prothrombin time （PT）, activated partial thromboplastin time （APTr） and thrombin time 0T） were detected and compared. Results SLE group DD, VWF： Ag, TM and t-PA were significantly higher （P 〈 0.01）; these four indicators of kidney damage group was also significantly higher than that of non-renal impairment group （P 〈 0.01）; Fq＇, APTY was significantly shorter （in comparison with the control group （P 〈 0.01）; however, for Tr and FIB, there were no significant differences between the two groups （P 〉 0.05）. Conclusion D-D, VWF： Ag, TM, FDP and t-PA levels in patients with SLE kidney were significantly associated with kidney damage. Further more, levels of these indicators were increased along with the severity of kidney damage.