| IL-6、STAT3表达对喉癌患者预后影响因素研究 |
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| 引用本文： | 代丽丽,刘亭彦,周雪华,魏庆宇,李圆,崔彩霞.IL-6、STAT3表达对喉癌患者预后影响因素研究[J].中国现代医生,2013,51(19):37-38. |
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| 作者姓名： | 代丽丽 刘亭彦 周雪华 魏庆宇 李圆 崔彩霞 |
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| 作者单位： | 杭州师范大学附属医院耳鼻咽喉-头颈外科,浙江杭州,310000 |
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| 基金项目： | 浙江省自然科学基金项目（LY12H13004） |
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| 摘 要： | 目的 探讨IL-6、STAT3表达对喉癌患者预后影响因素.方法 选择40例喉鳞状细胞癌患者,采用免疫组化SP法检测患者肿瘤组织和癌旁正常组织的IL-6、STAT3蛋白表达情况.结果 随访1年,发现IL-6和STAT3均阳性表达的27例患者中16例预后较差,占59.3％.IL-6、STAT3蛋白阳性表达率在TNM分期、淋巴结转移两个方面存在显著差异.结论 IL-6、STAT3蛋白表达与肿瘤的发生、发展以及预后密切相关.
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| 关 键 词： | IL-6 STAT3 预后 |
Influence factors of IL-6, STAT3 expression on the prognosis of patients with laryngeal cancer |
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| Authors: | DAI Lili LIU Tingyan ZHOU Xuehua WEI Qingyu LI Yuan CUI Caixia |
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| Institution: | ( Department of ENT ＆ HN Surgery, Hangzhou Normal University Affiliated Hospital, Hangzhou 310000, China) |
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| Abstract: | Objective To investigate influence factors of IL-6, STAT3 expression on the prognosis of patients with la ryngeal cancer. Methods Forty cases patients with laryngeal cancer were selected, streptavidin-Peroxidase （S-P） im- munohisto-chemical technique was used to examined the expression of IL-6 and Stat3 in tumor tissue and adjacent normal tissue. Results After 1 year follow-up, 16 of 27 cases patients with IL-6, STAT3 positive expression had poor prognosis. IL-6, STAT3 positive expression rate had significant difference in TNM stage, lymph node metastasis. Con- clusion IL-6 and STAT3 protein expression are closely related to tumor occurrence, development and prognosis. |
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| Keywords: | IL-6 STAT3 Prognosis |
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