心理护理对乳腺癌术后化疗患者血清细胞因子的影响

目的 探讨心理护理干预对乳腺癌术后化疗患者血清细胞因子的影响.方法 选择66例乳腺癌改良根治术患者,术后均接受化疗,随机分为心理干预组与对照组.两组在化疗中均接受常规治疗及护理,心理干预组进行心理护理干预.观察两组患者治疗前后Zung焦虑量表（SAS）、Zung抑郁量表（SDS）、症状自评量表（SCL-90）及血清白介素-2（IL-2）、白介素-4（IL-4）、γ-干扰素（IFN-γ）水平的变化.结果 两组患者化疗后的SAS、SDS、SCL-90评分均较化疗前明显升高（P〈0.05）,且对照组升高的幅度较心理干预组更明显（P〈0.05）;同时两组患者化疗后IL-2、IL-4、IFN-γ数值均较化疗前升高（P〈0.05或P〈0.01）,且心理干预组升高的幅度较对照组更明显（P〈0.05）.结论 心理护理干预治疗乳腺癌术后化疗患者能有效地改善患者不良情绪,提高患者血清细胞因子含量,增强患者免疫力.

Influence of psychological nursing intervention on serum cytokine of breast cancer patients treated with postoperative chemotherapy

Objective To discuss the influence of psychological nursing intervention on serum cytokine of breast can- cer patients treated with postoperative chemotherapy. Methods A total of 66 cases of patients treated with modified radical mastectomy for breast cancer were selected,and all the patients were treated with postoperative chemotherapy and divided into psychological intervention group and control group. All the patients in two groups were given routine medical treatment and nursing during the postoperative chemotherapy period, and the patients in psychological inter- vention group were given psychological nursing intervention additionally. All the following changes of patients in two groups were observed and compared before and after treatment：Zung Anxiousness Scale （SAS）, Zung Depression Scale, Symptom Checklist （SCL-90）, plasma interleukin-2 （IL-2）, interleukin-4 （IL-4） and IFN-~. Results The scores of SAS, SDS, SCL-90 of patients after postoperative chemotherapy in both groups had risen obviously than those before chemotherapy（P〈O.05）. Meanwhile, the values of IL-2, IL-4, and IFN-v of patients in two groups after chemotherapy had risen than those before chemotherapy （P〈0.05 or P〈0.01 ）, and the increase rate in psychological intervention group was more obvious than that in control group （P〈0.05）. Conclusion Psychological nursing interven- tion treatment can effectively improve the negative emotion of patients. Meanwhile, psychological nursing intervention treatment can effectively add the amount of serum cytokine, and enhance the immunity of patients.