nCPAP治疗阻塞性睡眠呼吸暂停低通气综合征合并心衰患者的临床观察

目的探讨经鼻面罩持续气道正压通气(nCPAP)治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并慢性充血性心力衰竭(CHF)患者的临床疗效。方法选取OSAHS合并CHF患者96例,随机分为两组:实验组52例患者接受常规药物治疗的同时进行nCPAP治疗;对照组44例患者仅接受常规药物治疗。治疗6个月后观察治疗前后睡眠呼吸暂停低通气指数(AHI)、最低血氧饱和度(minSaO2)、左室舒张末期内径(LVDd)、左室射血分数(LVEF)及B型尿钠肽值(BNP)值的变化。结果实验组在常规药物联合nCPAP治疗6个月后,AHI、LVDd、BNP值较对照组明显下降,而最低SaO2、LVEF则明显升高(P<0.01)。结论 nCPAP治疗可消除呼吸暂停,纠正低氧血症,改善心力衰竭,对提高患者的治愈率和生活质量具有重要意义。

Clinical observation of nasal .continuous positive airway pressure treatment for obstructive sleep apnea hypopnea syndrome with chronic heart failure

Objective To observe the clinical effectiveness of nasal continuous positive airway pressure（nCPAP） treatment for obstructive sleep apnea hypopnea syndrome （OSAHS） combined with chronic heart failure （CHF）. Methods Ninety-six OSAHS combined with CHF patients were randomly divided into two groups： the experimental group was 52 cases accepted conventional treatments combined with nCPAP treatment; The control group was 44 cases only accepted conventional treatments. After treatment for 6 months, Apnea Hyponea lndex（AHI）,minimum blood oxygen saturation （minSaO2）,Left ventricular end-diastolic diameter （LVDd）,Left ventricular ejection fraction （LVEF） and B-type natriuretic peptide value （BNP） were observed. Results After 6 months treatment, the experimental group of AHI,LVDd, BNP value were significant lower than those of the control group;minSaO2 and LVEF increased significantly（P 〈 0.01 ）. Conclusion nCPAP treatment can eliminate apnea, correct hypoxia, improve heart failure and improve the cure rate and quality of life of patients.