三种药物治疗方案对未破裂异位妊娠的疗效观察

目的探讨三种药物治疗方案对未破裂异位妊娠的疗效。方法对2001年1月，2007年12月我院收治并采用药物治疗的未破裂型异位妊娠132例进行疗效分析。随机分成Ⅰ、Ⅱ、Ⅲ组：Ⅰ组采用甲氨蝶呤（MTX）50mg/m^2，加液隔日静滴三次。四氢叶酸6mg隔日肌注3次；Ⅱ组在同Ⅰ组方案同时加用米非司酮25mg，每日2次口服，连用3d；Ⅲ组在同Ⅰ组方案同时加用中药异位妊娠方加减煎服。结果Ⅰ组治愈率75％（35／44），Ⅱ组治愈率77．27％（34/44），Ⅲ组治愈率93．18％（41／44）。Ⅰ组与Ⅲ组、Ⅱ组与Ⅲ组间比较差异有显著意义（P均〈0．05）；Ⅰ组与Ⅱ组比较差异无显著意义（P〉0．05）。结论应用MTX全身用药治疗未破裂异位妊娠疗效确切，加用米非司酮未明显增加疗效，而加用中药治疗，能明显提高治愈成功率。

Observation of Curative Effects of Three Therapeutic Schemes for Unruptured Ectopic Pregnancy

Objective To explore the effects of three therapeutic schemes for unruptured ectopic pregnancy. Methods From January 2001 to December 2007,132 cases with unruptured ectopic pregnancy treated with drugs of Qidong hospital of Traditional Chinese Medicine were undergone analysis of therapeutic effect. These patients were randomly divided into 3 groups：group Ⅰ , Ⅱ, Ⅲ. The group Ⅰ were administrated intravenous drip of methotrexate（MTX） 50 mg/m^2 for 3 times every other day and intramuscular injection of coenzyme F（CF） 6 mg for 3 times every other day. In addition to treatment of group, the group Ⅱ were administered additional mifepristone 25 mg orally,twice daily for 3 days. The group Ⅲ were treated by modified Traditional Chinese Medicine （TCM） decoction for ectopic pregnancy with the exception of treatment of group Ⅰ. Results The curing rate of group Ⅰ, Ⅱ, Ⅲ were 75%（35/44）,77.27%（34/44）, 93.18%（41/44）, respectively. The significant differences were found between group Ⅰ and Ⅲ, group Ⅱ and Ⅲ （P 〈 0.05）, but there was no significant difference between group Ⅰ and Ⅱ （P 〉 0.05）. Conclusion MTX is effective in the treatment of unruptured ectopic pregnancy,and combination of TCM instead of mifepristone can significantly improve the success rate of healing.