青年急性心肌梗死患者CD4^＋IFN-γ^＋细胞及血清Lp-PLA2水平研究

目的探讨青年急性心肌梗死患者干扰素-γ（IFN-γ）在辅助型T淋巴细胞（Th细胞／CD4＋细胞）中的比例、血清脂蛋白相关磷脂酶A2（Lp—PLA2）水平及临床意义。方法初发急性心肌梗死青年患者56例（A组），健康青年对照组30例（B组），流式细胞术（method of flow cytometry，FCM）检测CD4^＋IFN-γ双阳性细胞比例，酶联免疫吸附法（ELISA）检测血清Lp—PLA2浓度。结果A组患者CD4＋IFN-γ^＋双阳性细胞比例及血清Lp—PIA2浓度均显著高于B组（P〈0．01）。结论IFN-γ在Th细胞中的比例及血清Lp—PLA2的浓度对青年急性心肌梗死发病机制提供新思路。性心

CD4+IFN-γ+Cells and Serum Lp-PLA2 Level in Young Patients with Acute Myocardial Infarction

Objective To explore the proportion of interferon-γ（IFN-γ） and the serum lipoprotein-assoeiated phospholipase A2 （Lp-PLA2） level in the T helper lymphocytes （Th cell/CD4^＋cell）in young patients with acute myocardial infarction and clinical significance. Methods Group A included 56 cases of original onset of young acute myocardial infarction and Group B , 30 cases of healthy young controls. The flow cytometry was used to detect the CD4^＋IFN-γ^＋ double positive cell level and the enzyme-linked immunosorbent assay（ELISA） to detect the serum Lp-PLA2 level. Results The CD4^＋IFN-γ^＋ double-positive cell level and the serum Lp-PLA2 level were significantly higher in Group A than those in Group B （P〈0.01）. Conclusion The IFN-γ in the proportion of Th cells and the serum Lp-PLA2 level have the predictive value in the incidence of acute myocardial infarction in young people, which provides a new approach to the pathogenesis of acute myocardial infarction in young people in inflammation and immunity ways.