急性重症胰腺炎血行感染患者肠屏障功能障碍的临床研究

目的探讨急性重症胰腺炎血行感染患者与肠道屏障的临床相关性研究，并观察急性重症胰腺炎血行感染和术后感染之间的联系。方法对我院40例接受急性重症胰腺炎治疗并确诊为血行感染的患者进行临床分组治疗，对照组采用常规治疗，治疗组在对照组治疗基础上实施肠屏障早期保护措施，比较两组胃肠功能评分和APACHEⅡ评分、C-反应蛋白（CRP）、血清肿瘤坏死因子-α（TNF-α）、血浆内毒素水平（LPS）、尿乳果糖，甘露醇值（UM），并对两组患者的治疗后一般情况进行比较。结果观察组治疗后APACHEⅡ评分、CRP、TNF—-α、LPS均较治疗前有硅著下降，与对照组比较差异亦有高度统计学意义（P〈0．01）。结论早期进行肠屏障功能保护能有效提高患者胃肠功能，降低肠屏障通透性和炎性反应。

Clinical research of intestinal barrier dysfunction for severe acute pancreatitis patients with blood line infections

Objective To study the patients with acute clinical correlation research and observation for severe pancreatitis blood line infection patients with intestinal barrier acute pancreatitis blood line infection and the relationship be- tween postoperative infection. Methods The data and cases accepted treatment for severe acute pancreatitis and diag- nosed with blood line infected patients clinical treatment group, control group with the conventional treatment, the treatment group in the control group treatment on the basis of implementation of intestinal barrier early protection measures. Compared two groups gastrointestinal function score and APACHE II score, C-reactive protein （CRP）, serum tumor necrosis factor alpha （TNF alpha）, plasma endotoxin level （LPS）, urinary lactulose/mannitol value （L/M）, and the two groups after treatment in patients with general condition comparison. Results The observation group after treatment, APACHE il score, CRP, TNF alpha, LPS than before treatment down significantly, compared with controls differences also had statistical significance（P 〈 0.01 ）. Conclusion Early intestinal barrier function can effectively im- prove the protection of patients with gastrointestinal function, reduce the intestinal barrier permeability and inflamma- tory reaction.