| 细胞因子IL-1β和TNF-α在骨关节炎软骨中mRNA表达的变化及意义 |
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| 引用本文： | ZHANG Tiefeng,李景峰.细胞因子IL-1β和TNF-α在骨关节炎软骨中mRNA表达的变化及意义[J].中国现代医生,2008,46(15):116-117. |
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| 作者姓名： | ZHANG Tiefeng 李景峰 |
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| 作者单位： | 辽宁省锦州市中心医院骨科,辽宁锦州,121000 |
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| 摘 要： | 目的探讨IL-1β和TNF-α mRNA在大鼠实验性骨关节炎软骨表达的变化和意义。方法采用Hulth法制作大鼠膝关节0A动物模型，于术后8周取标本并观察关节软骨形态，RT—PCR技术检测mRNA表达。结果0A模型侧关节软骨的IL-1β和TNF-α mRNA表达均高于对照侧。结论OA软骨中存在IL-1β和TNF-α mRNA表达的上调，可能是OA的发病机制之一。
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| 关 键 词： | 骨关节炎 IL-1β TNF-α |
Expression and Significance of Cytokine IL-β and TNF-α mRNA in Osteoarthritis Cartilage |
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| Authors: | ZHANG Tiefeng LI Jingfeng |
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| Institution: | (Department of Orthopaedics, Central Hospital of Jinzhou, Liaoning 121000) |
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| Abstract: | Objective To explore the expression and significance of cytokine IL-1β and TNF-α mRNA in rat cartilage with experimental osteoarthritis. Methods The animal models of experimental OA in rat knee joint were established with Hulth method. The articular cartilages were harvested after 8 weeks. Morphological changes were found through observing the appearance of cartilage and the expression of mRNA was detected through RT-PCR techniques. Results The expression of IL-1β and TNF-α mRNA in OA models was statistically more than that in controls. Conclusion The up-expression of IL-1β and TNF-α mRNA might be a possible mechanism of OA. |
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| Keywords: | Osteoarthritis IL-1β TNF-α |
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