贵阳市老年人群维生素D水平及与老年性疾病的相关性研究

目的探讨贵阳市老年人群维生素D水平及与老年性疾病的相关性。方法收集2013年4月～2019年6月在贵阳市第一人民医院进行过维生素D检查的老年患者资料,共5913例,检测患者血清25-羟维生素D_3。检测结果分为维生素D缺乏、不足、正常情况,按临床诊断分组,分为高血压组、心力衰竭组、脑卒中组、糖尿病组及健康对照组5组,结合临床资料进行回顾性分析,探讨贵阳市老年人群维生素D水平及与老年性疾病的相关性。结果 25-羟维生素D_3平均水平为20.797 ng/mL,其中25-羟维生素D_3缺乏(20 ng/mL)3137例,占53.03%;维生素D_3不足(20 ng/mLD_330 ng/mL)1722例,占29.13%;维生素D_3正常(30 ng/mL)1054例,占17.84%。健康正常对照组维生素D_3水平显著高于血压组、心力衰竭组、脑卒中组和糖尿病组(P0.05),而高血压组、心力衰竭组、脑卒中组、糖尿病组在血清25(OH)D水平上无统计学差异(P0.05),高血压组、心力衰竭组、脑卒中组、糖尿病组不同严重程度间的血清25(OH)D水平具有统计学差异(P0.05),病情严重程度越高,血清25(OH)D水平越低,血清25(OH)D水平与高血压、心力衰竭、脑卒中、糖尿病等老年性疾病存在负相关(P0.05)。结论贵阳市老年人维生素D水平显著低于正常,老年人群维生素D水平与老年性疾病明显相关,适量补充维生素D有可能成为预防和治疗老年性疾病的有效手段。

Correlation between vitamin D levels and senile diseases in the elderly in Guiyang

Objective To investigate the relationship between vitamin D levels and senile diseases in the elderly in Guiyang.Methods A total of 5913 elderly patients who underwent vitamin D examination in Guiyang First People''s Hospital from April 2013 to June 2019 were enrolled.The serum 25-hydroxyvitamin D3test results were divided into vitamin D deficiency,lack and normality.According to the clinical diagnosis,the patients were divided into hypertension group,heart failure group,stroke group,diabetes group and healthy control group.The clinical data were retrospectively analyzed.The relevance of vitamin D level and senile diseases in the elderly in Guiyang was explored.Results The average level of 25-hydroxyvitamin D3was 20.797 ng/mL,of which there were 3137 cases of 25-hydroxyvitamin D3deficiency(<20 ng/mL),accounted for 53.03%;1722 cases of vitamin D3insufficiency(20 ng/mL30 ng/mL),accounted for 17.84%.The level of vitamin D3in healthy normal control group was significantly higher than that in hypertension group,heart failure group,stroke group and diabetes group(P<0.05).There were no significant differences in serum 25(OH)D levels between the hypertension group,the heart failure group,the stroke group,and the diabetes group(P>0.05).Serum 25(OH)D levels were statistically different between different severity in the hypertension group,the heart failure group,the stroke group,and the diabetes group(P<0.05).The higher the severity of the disease,the lower the serum 25(OH)D level.There was a negative correlation between the serum 25(OH)D level and senile diseases such as hypertension,heart failure,stroke and diabetes(P<0.05).Conclusion Vitamin D levels in the elderly in Guiyang are significantly lower than normal.Vitamin D levels in the elderly are significantly associated with senile diseases.Appropriate vitamin D supplementation may be an effective means of preventing and treating senile diseases.