替罗非班对心肌梗死急诊介入术中无复流的影响

目的观察替罗非班对急性ST段抬高心肌梗死急诊冠状动脉介入无复流现象的治疗效果。方法冠状动脉介入术中出现无复流现象45例,依次给予硝酸甘油、维拉帕米和替罗非班,观察靶血管前向血流的TIMI分级。结果替罗非班可以明显改善PCI术中无复流现象,替罗非班组与硝酸甘油组或维拉帕米组比较差异有显著性,硝酸甘油组与维拉帕米组比较差异无统计学意义。术中即刻效果不理想者,持续应用替罗非班,24h再次造影均改善了无复流。结论替罗非班可以明显改善急性ST段抬高心肌梗死急诊冠状动脉介入无复流现象。

Effect of Tirofiban on No-reflow in Interventional Treatment of Myocardial Infarction

Objective To observe the effect of tirofiban on the no-reflow phenomenon in acute ST-segment elevation myocardial infarction percutaneous coronary intervention. Methods No-reflow phenomenon occurred in 45 cases in the coronary intervention, and nitroglycerin, verapamil and tirofiban were given in turn. The target vessel forward flow of TIMI grade was observed. Results Tirofiban could improve no-reflow phenomenon in PCI technique, and there was a significant difference between the tirofiban group and the nitroglycerin group or between the tirofiban group and the verapamil group and there was no significant difference between the nitroglycerin group and the verapamil group. Immediate surgery showed no effect, and after sustained application of tirofiban, 2dh radiography showed the improvement of the no-fellow. Conclusion Tirofiban can significantly improve the no-reflow phenomenon in acute ST-segment elevation myocardial infarction percutaneous coronary intervention.