河司匹林联合低分子肝素治疗30例习惯性流产合并抗磷脂综合征的临床观察

目的分析阿司匹林联合低分子肝素治疗习惯性流产的疗效。方法将91例不明原因习惯性流产患者随机分为阿司匹林组（单药治疗组）、低分子肝素联合阿司匹林组（联合治疗组）和安慰剂组（对照组），用药时间从宫内妊娠确诊开始直至临产或者发生流产、早产，比较组间的活产率、流产率、产科并发症以及母婴不良结局发生率。结果单药治疗组、联合治疗组及对照组活产率、流产率、分娩孕周、瘀斑组间比较，差异有统计学意义（P〈0．05）。联合治疗组优于其他两组。结论阿司匹林联合低分子肝素治疗能有效改善抗磷脂综合征习惯性流产患者的妊娠结局。

The effect of aspirin combined with low molecular weight heparin in treatment of 30 patients with habitual abortion and anti-phospholipid syndrome

Objective To compare the efficacy of aspirin and aspirin combined with low molecular weight heparin in treatment of habitual abortion.Methods All of 91 patients with unexplained habitual abortion were randomly divided into aspirin group(single drug group) and aspirin combined with low molecular weight heparin group(combine drug group) and placebo group(control group).Medication time was pregnancy to parturient or abortion or premature delivery.The rate of live birth and the rate of abortion and obstetric complication and the rate of adverse outcome with maternal and child.Results The rate of live birth and the rate of abortion and the gestational weeks of delivery and petechia were all significant among single drug group and combine drug group and control group(P < 0.05).Conclusion Aspirin combined with low molecular weight heparin can improve the pregnancy outcome of the patients with habitual abortion and anti-phospholipid syndrome.