血管性轻度认知损害患者血清胱抑素C水平的临床研究

目的探讨血管性轻度认知功能损害（V-MCI）与血清胱抑素C（Cys C）的相关性。方法对70例血管性轻度认知功能损害（V-MCI组）和67例认知功能正常对照组（非V-MCI组）进行详细临床评估和血清Cys C测定。结果 V-MCI组Cys C水平明显高于非V-MCI组（P〈0.05）,其Cys C水平与MoCA评分中的视空间/执行功能、命名、注意与计算力、语言、延迟回忆各亚项的评分及其总分呈明显负相关（P〈0.05）。结论高Cys C可能是V-MCI的独立危险因素,Cys C水平可能与认知功能损害的程度相关。

Changes of serum cystatin C in vascular mild cognitive impairment

Objective To investigate the relationship between mild vascular cognitive impairment（V-MCI） and serum cystatin C（Cys C）.Methods The levels of Cys C and clinical features were measured in 70 patients with V-MCI and in 67 controls with normal cognition.Results Serum Cys C level of V-MCI group was deepest higher than non-V-MCI group（P 0.05）;serum Cys C level of V-MCI group had negative correlated with total MoCA score（P 0.05） and subitem scores on spatial/executive ability,attention/counting,naming,language,delayed recall（P0.05）.Conclusion The high level of serum cystatin C may be an independent risk factor for V-MCI.The higher level of serum Cystatin C correlated with the degree of cognitive impairment.