首页 | 本学科首页   官方微博 | 高级检索  
检索        

大肠癌危险因素的Meta分析
引用本文:陈坤,裘炯良,张扬.大肠癌危险因素的Meta分析[J].浙江大学学报(医学版),2002,31(4):254-258.
作者姓名:陈坤  裘炯良  张扬
作者单位:浙江大学医学院,浙江杭州,310031
基金项目:国家自然科学基金资助项目 ( 3 0 170 82 8)
摘    要:目的:综合分析我国大肠癌发病的危险因素。方法:运用Meta-analysis方法对国内有关大肠癌危险因素的14个病例对照研究结果进行了定量综合分析,累计病例、对照数分别为5034和5205例,统计处理采用Dersimonian和Larid的随机效应模型。结果:对14个研究的Meta分析表明:轻体力活动、膳食纤维为保护因素(综合OR均小于0.8);粘液血便、慢性腹泻和大肠息肉史与大肠癌有较高的关联(综合OR均大于4)。分层结果显示,某些因素在南北地区间或采用不同的指示病例和对照类型间危险度估计存在着一定差异。结论:肠道相关症状或疾病、饮食因素中的油腻性食物等、精神刺激和家族钟瘤史与大肠癌的发生有关,而轻体力活动,而轻体力活动、膳食纤维为保护性因素。

关 键 词:大肠癌  危险因素  Meta分析  流行病学  病例对照研究
文章编号:1008-9292(2002)04-0254-05
修稿时间:2001年4月11日

Meta-analysis study on risk factors of colorectal cancer
CHEN Kun,QIU Jiong liang,ZHANG Yang.Meta-analysis study on risk factors of colorectal cancer[J].Journal of Zhejiang University(Medical Sciences),2002,31(4):254-258.
Authors:CHEN Kun  QIU Jiong liang  ZHANG Yang
Abstract:Objective: To evaluate the risk factors of colorectal cancer in China. Methods: The results of 14 case control studies from 1988 to 2000 were analyzed by means of Meta analysis. The total numbers of cases and controls were 5034 and 5205 respectively. Dersimonian and Laird random effective models were applied in proces sing data. Results: Light physical activities and dietary fibers were protective factors (pooled OR <0.8); while histories of fecal mucohemorrhage, chronic diarrhea and bowel polyps were highly associated with colorectal cancer (pooled OR >4). The stratified results indicated that there were probably some differences between OR values of some factors if using different sources of cases and controls or using different data from the north and south of China. Conclusion: Risks of colorectal cancer are significantly associated with the histories of intestinal diseases or re lative symptoms, fatty food, psychic attack and family history of cancers. The light physical activities and dietary fibers are probably protective factors.
Keywords:Colorectal neoplasms/epidemiol  Risk factor  Colorectal cancer  Case  control study  Meta  analysis
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号