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骨质疏松大鼠胫骨元素含量变化及相关性研究
引用本文:郑高利,郑筱祥,张信岳,金锋,陈凯,龚维桂.骨质疏松大鼠胫骨元素含量变化及相关性研究[J].浙江大学学报(医学版),2002,31(3):185-188.
作者姓名:郑高利  郑筱祥  张信岳  金锋  陈凯  龚维桂
作者单位:1. 浙江大学生物医学工程与仪器科学学院,浙江,杭州,310027
2. 浙江省医学科学院药物研究所,浙江,杭州,310013
基金项目:浙江省自然科学基金 (3990 37)
摘    要:目的:观察骨质疏松症骨骼中元素含量量变化及其相互的关系。方法:10月龄雌性SD大鼠切除双侧卵巢(去卵巢模型组),并设假手术组,7个月后取胫骨,原子吸收分光光度法测定Ca、P、Mg、Zn、Mn、Fe、Cu、Co、Mo和Cr含量,并对各元素的含量之间进行一元回归分析。结果:骨质疏松症模型大鼠胫骨除Ca、P和Mg等常量元素分别下降6.6%(P<0.05)、6.3%(P<0.05)和14.9%(P<0.01)以外,微量元素Zn和Fe分别下降15.2%(P<0.01)和35.1%(P<0.01),Mo和Cr分别下降12.2%(P>0.05)和14.0%(P>0.05),而Mn、Cu和Co则无明显改变;Mg、Mn和Zn等元素含量与Ca、P经一元回归分析具有显著的相关性。结论:去卵巢骨质疏松症模型大鼠骨骼Ca、P、Mg、Zn和Fe等含量明显下降。

关 键 词:骨质疏松  大鼠  胫骨            动物疾病模型  微量元素
文章编号:1008-9292(2002)03-0185-04
修稿时间:2001年4月23日

Changes of element contents and their interrelationship in tibia of osteoporotic rats
ZHENG Gao-li,ZHENG Xiao-xiang,ZHANG Xin-yue,et al.Changes of element contents and their interrelationship in tibia of osteoporotic rats[J].Journal of Zhejiang University(Medical Sciences),2002,31(3):185-188.
Authors:ZHENG Gao-li  ZHENG Xiao-xiang  ZHANG Xin-yue  
Abstract:Objective: To observe the changes of bone element contents in osteoporosis and their interrelationship. Methods: Twelve female SD rats, 10 month old, were bilaterally ovariectomized (OVX group) and another ten rats were received sham operation under anesthesia (SHAM group). The element contents in tibia, including Ca, P, Mg, Zn, Mn, Fe, Cu, Co, Mo and Cr, were determined by atomic absorption spectrophotometer 7 month later. The data of contents of all elements were analyzed by simple regression. Results: Compared with the SHAM group rats, the contents of Ca, P and Mg were decreased by 6.6%( P <0.05), 6.3%( P <0.05) and 14.9%( P <0.01) respectively. The contents of Zn and Fe were reduced by 15.2%( P <0.01) and 35.1%( P < 0.01 ) separately, Mo and Cr were decreased by 12.2%( P >0.05) and 14.0%( P >0.05), while the contents of Mn, Cu and Co were shown no change. There was a significant correlation among the contents of Mg,Mn,Zn,Ca and P. Conclusion: The contents of Ca,P,Mg,Zn and Fe were markedly reduced in bone of osteoporotic rats induced by ovariectomy.
Keywords:Osteoporosis  Element  Calcium  Phosphorus  Manganese  Zinc  Iron  Disease models  animal  Rat
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