| 尼克酰胺磷酸核糖转移酶与衰老及衰老相关疾病研究进展 |
| |
| 作者姓名： | Wang F Zhang WP |
| |
| 作者单位： | 浙江大学医学院药理学教研室,浙江杭州,310058 |
| |
| 摘 要： | 哺乳动物尼克酰胺磷酸核糖转移酶(nicotinamide phosphoribosyl transferase,NAMPT),参与NAD的合成,也是一种细胞因子,参与调控糖代谢、炎症反应、应激耐受等多种生物学效应.研究表明,NAMPT与衰老及衰老相关疾病(例如糖尿病、肥胖、肿瘤、神经退行性疾病以及心脑血管疾病等)密切相关.这些研究成果将为临床防治衰老相关疾病提供新的思路和方法.
|
| 关 键 词： | 烟酰胺磷酸核糖基转移酶 NAMPT 衰老 糖尿病 肥胖症 肿瘤 神经退行性疾病 心脑血管疾病 |
Research progress on nicotinamide phosphoribosyl transferase involved in aging and age-related diseases |
| |
| Wang F,Zhang WP.Research progress on nicotinamide phosphoribosyl transferase involved in aging and age-related diseases[J].Journal of Zhejiang University(Medical Sciences),2011,40(6):680-684. |
| |
| Authors: | Wang Feng Zhang Wei-ping |
| |
| Institution: | WANG Feng,ZHANG Wei-ping(Department of Pharmacology,College of Medicine,Zhejiang University,Hangzhou 310058,China) |
| |
| Abstract: | Nicotinamide phosphoribosyl transferase(NAMPT) is the key enzyme for the synthesis of nicotinamide adenine dinucleotide(NAD),and also serves as a cytokine in mammalian cells.NAMPT is known to participate in biological responses such as glucose metabolism,inflammatory response and stress.Recent studies have revealed that NAMPT is closely associated with aging and age-related diseases such as diabetes,obesity,cancers,neuronal degeneration and cardiovascular diseases.Research on NAMPT may provide insight on pr... |
| |
| Keywords: | Nicotinamide phosphoribosyltransferase NAMPT Aging Diabetes mellitus Obesity Neoplasms Neuronal degeneration disease Cardiovascular diseases |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
