| 改善睡眠口服液质量标准研究 |
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| 引用本文： | 郑飞,;于珊珊,;越皓,;刘淑莹.改善睡眠口服液质量标准研究[J].长春中医药大学学报,2014(6):995-998. |
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| 作者姓名： | 郑飞 ;于珊珊 ;越皓 ;刘淑莹 |
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| 作者单位： | [1]长春中医药大学,长春130117; [2]中国科学院长春应用化学研究所,长春130022 |
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| 基金项目： | 公益性行业科研专项（201303111）; 国家科技支撑计划（2011BAI03B00） |
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| 摘 要： | 目的建立改善睡眠口服液的质量标准。方法采用薄层色谱法对酒制五味子及红参进行薄层鉴别,采用高效液相色谱法测定五味子醇甲的含量,紫外分光光度法测定人参总皂苷的含量;同时对p H值、相对密度等进行检查。结果薄层鉴别斑点清晰,阴性无干扰;五味子醇甲在浓度为0.180 2-0.485 6 mg范围内呈良好线性关系,平均回收率为100.19%;总皂苷在浓度为0.080 8-0.242 4 mg/m L范围内呈良好线性关系,平均回收率为101.35%。结论本方法简便可行,灵敏度高,可用于改善睡眠口服液的质量控制。
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| 关 键 词： | 改善睡眠口服液 薄层色谱法 高效液相色谱法 质量标准 |
Quality control of oral liquid for improvement of sleep |
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| Institution: | ZHENG Fei, Yu Shanshan, YUE Hao, LIU Shuying ( 1. Changchun University of Traditional Chinese Medicine, Changchun 130117, China; 2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China) |
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| Abstract: | Objectlve To establish the quality standard for Oral Liquid for improvement of sleep. Methods TLC was used for qualitative identification of Fmctus Schisandrae of steaming with wine and Red Ginseng; the content of Schisandrin was determined by HPLC ; the content of total saponins was determined by UV; the relative density and pH value were measured. Results The spots on TLC plates were clear without interference by the blank reference; schisandrin showed a good linear re- lationship at the range of 0. 180 2 - 0.485 6 mg/mL, the average recovery was 100.19 %. Total saponins showed a good lin- ear relationship at the range of 0. 080 8 -0. 242 4 mg/mL, the average recovery was 101.35 %. Conclusion This estab- lished quality control method was simple, feasible and high sensitivity, specific and reproducible, which could be applied to quality assessment of Oral Liquid for improvement of sleep. |
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| Keywords: | oral liquid for improvement of sleep TLC HPLC quality standard |
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