| 大剂量厄贝沙坦治疗糖尿病肾病的临床疗效观察 |
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| 引用本文： | 梁斌,黄斌.大剂量厄贝沙坦治疗糖尿病肾病的临床疗效观察[J].四川医学,2011,32(7):1081-1082. |
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| 作者姓名： | 梁斌 黄斌 |
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| 作者单位： | 成都市第二人民医院内分泌科,四川成都,610017 |
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| 摘 要： | 目的观察大剂量的厄贝沙坦对糖尿病肾病（DN）患者疗效的影响。方法糖尿病肾病（DN）患者50例,随机（信封发）分为治疗组（大剂量厄贝沙坦组）以及对照组（小剂量厄贝沙坦组）,4周后比较治疗效果及药物不良反应。结果两组患者血压都有降低,但两组差异无统计学意义（P〉0.05）,尿清蛋白均显著下降（Pa〈0.01,Pb〈0.05）,大剂量组治疗后尿清蛋白下降更为显著,其效果优于小剂量组（P〈0.05）。结论大剂量厄贝沙坦的应用对DN患者有独立于血压之外的肾脏保护作用,安全性好。
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| 关 键 词： | 厄贝沙坦 糖尿病肾病 尿清蛋白 |
High-dose Irbesartan treatment of diabetic nephropathy clinical curative effects |
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| LIANG Bin,HUANG Bin.High-dose Irbesartan treatment of diabetic nephropathy clinical curative effects[J].Sichuan Medical Journal,2011,32(7):1081-1082. |
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| Authors: | LIANG Bin HUANG Bin |
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| Institution: | .(The Second People′s Hospital of Chengdu,Chengdu,Sichuan 610017,China ) |
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| Abstract: | Objective To observe the High-dose Irbesartan treatment diabetic nephropathy（DN） patients the effect of adenoidectomy.Methods Diabetic nephropathy（DN） patients 50 cases（envelope hair）,randomly divided into the treatment group（high-dose Irbesartan group,n=25） and control group（small doses of Irbesartan group,n=25）,4 weeks after comparing therapeutic effect and medication side-effects.Results Two groups of patients had lower blood pressure,but the two groups difference was statistically significant（P0.05）,urinary albumin were significantly decrease（Pa0.01,Pb0.05）,high-dose Irbesartan groups after treating urinary albumin decline,the effect is more significant than small dose group（P0.05）.Conclusion High-dose Irbesartan application on the DN patients have independent of blood pressure outside of the renal protection effect,good safety. |
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| Keywords: | irbesartan diabetic nephropathy proteinuria |
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