心肺复苏中血管加压素与肾上腺素的联合应用

目的研究血管加压素联合肾上腺素的应用在心肺复苏中的疗效。方法 216例心跳骤停患者,随机分成3组：肾上腺素标准剂量组（A组）75例;血管加压素（小剂量）＋肾上腺素（B组）72例;血管加压素（大剂量）＋肾上腺索（C组）69例,各组分别观察自主循环恢复率、存活率、自主循环恢复时间。各组在应用复苏药物的同时,均持续胸外心脏按压、气管插管机械通气,持续心电、血压监测、出现室颤予以电除颤。结果 A组、B组、C组自主循环恢复率分别为18.67%3、3.33%、43.48%,C组和B组明显高于A组（P〈0.05）。C组存活率（45.2%）显著高于A组（5.7%）和B组（11.2%）（分别P〈0.01,P〈0.05）;B组和C组自主循环恢复时间明显短于A组（分别P〈O.05,P〈O.01）。结论心肺复苏期间联合应用血管加压素和肾上腺素比单独应用肾上腺素明显提高自主循环恢复率和存活率,缩短自主循环恢复时间,尤以大剂量血管加压素联合肾上腺素为显著。

Cardiopulmonary resuscitation vasopressin and epinephrine in combination

Objective To study the vascular pressure rope epinephrine during cardiopulmonary resuscitation efficacy.Methods 216 patients with cardiac arrest were randomly divided into 3 groups： standard-dose epinephrine group（A group） 75 cases;vasopressin（low dose）＋epinephrine（B） 72 cases;vasopressin（large dose）＋adrenal cable（C）,69 cases were observed in each group return of spontaneous circulation,survival,recovery time of spontaneous circulation.Recovery of drugs in each group,while in the application are continuing chest cardiac compression,intubation and mechanical ventilation,continuous ECG,blood pressure monitoring,defibrillation appears to be ventricular fibrillation.Results group A,group B,group C restoration of spontaneous circulation rates were 18.67%,33.33%,43.48%,group C and B group was significantly higher than the group A（P0.05）.Group C survival rate（45.2%） was significantly higher than the group A（5.7%） and B（11.2%）（respectively P0.01,P0.05）;group B and group C was significantly shorter recovery time of spontaneous circulation in the group A（respectively,P0.05,P0.01）.Conclusion During cardiopulmonary resuscitation combined vasopressin and epinephrine compared with epinephrine alone significantly improve restoration of spontaneous circulation and survival rates,shortened the recovery time of spontaneous circulation,especially in high-dose vasopressin as a significant co-epinephrine.