| 食管手术预防性抗生素使用的随对照研究 |
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| 引用本文： | 赵雍凡,蒋雷,尹维佳,石应康.食管手术预防性抗生素使用的随对照研究[J].四川医学,2001,22(1):12-13. |
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| 作者姓名： | 赵雍凡 蒋雷 尹维佳 石应康 |
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| 作者单位： | 华西医科大学附属第一医院 |
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| 基金项目： | 本课题受四川省卫生厅科学研究资金资助(F981049) |
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| 摘 要： | 目的 探讨抗生素在预防食管手术后感染中的合理应用。方法 将给药方案分成头孢三嗪单剂组和4剂组，用随机对照试验方法对320例病人进行了多个指标的比较。结果 两组病例的术后感染率是8．28％和9．82％，平均住院日是17．53天和17．66天，两项指标无差异。成本效果比率是180．44元和734．05元，两组间有显著差异。结论 食管手术预防性使用抗生素只需在手术日使用即可真情以预防术后感染的作用。
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| 关 键 词： | 食管手术 抗生素 预防性使用 随机对照研究 |
| 文章编号： | 1004-0501(2001)01-0012-02 |
| 修稿时间： | 2000年10月12 |
A randomized controlled trial of preventive antibiotics used for esophageal operations. |
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| Zhao Yongfan,Jiang Lei,Yin Weijia,et al..A randomized controlled trial of preventive antibiotics used for esophageal operations.[J].Sichuan Medical Journal,2001,22(1):12-13. |
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| Authors: | Zhao Yongfan Jiang Lei Yin Weijia |
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| Institution: | Zhao Yongfan,Jiang Lei,Yin Weijia,et al.Department of Thoracie Cardiovascular Surgery,the First University Hospital of West China University of Medical Sciences,Chengdu,610041. |
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| Abstract: | Objective To find a reasonable method of using preventive antibiotics in the operation for esophageal carcinoma.Methods 320 patients were divided into2 groups by randomization.One group recived a single dose of cefotriaxon on the operating day only;the other group received a dose of cefotriaxon on the operating day and on the first 3 days after operation.A comparison of variables were made between the 2 groups.Results No significant differences were observed between the 2 groups in the postoperative infection rate (8.28% vs 9.82%)and the average hospital stay(17.53 days vs 17.66 days),but there was a significant difference between them in the ratio of cost-effects (180.44 yuan vs 734.05 yuan).Conclusion Administering antibiotics on the operating day only is the method of choice for the prevention of infection in esophageal operations. |
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| Keywords: | Preventive antibiotics Esophageal operation Randomized controlled trial |
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