FAF1、Livin蛋白在胃癌组织中的表达及临床意义

目的 探讨胃癌患者胃癌组织中FAF1、Livin蛋白的表达变化及其临床意义.方法 用免疫组化染色SP法检测53例胃癌患者病变组织及50例浅表性胃炎患者正常胃黏膜组织中FAF1、Livin蛋白的表达水平,并进行相关性分析.结果 胃癌组织中FAF1蛋白表达率（28.30％,15/53）明显低于正常胃黏膜组织（84.00％,42/50） （P ＜0.05）;Livin蛋白表达率（73.58％,39/53）明显高于正常胃黏膜组织14.00％ （7/50） （P ＜0.05）;在胃癌组织中FAF1蛋白表达与胃癌组织学分化程度有关（P＜0.05）;Livin蛋白表达与胃癌肿瘤大小、浸润深度、分化程度、癌细胞转移及TNM分期有关（P＜0.05）;FAF1、Livin蛋白在胃癌组织中的表达水平无相关性（r,=0.307,P＞0.05）.结论 FAF1蛋白的表达缺失可能参与胃癌的形成并抑制组织细胞的分化.胃癌的发生、发展、浸润、转移可能与Livin蛋白异常高表达有关.联合检测FAF1、Livin蛋白为胃癌的早期诊断及推断演进方向提供重要依据.

The expression of FAF1 and Livin proteins in gastric carcinoma and its clinical significance

Objective To explore the expression of FAF1 protein and Livin protein in gastric cancer tissues and its significance. Methods The expression of FAF1 protein and Livin protein was detected in 53 cases of gastric cancer and 50 normal subjects using im- munohistochemical methods, respectively. Results （1）The positive rate of FAF1 expression in the gastric cancer tissues was lower than that in the normal tissues （ 28.30% vs 84.00% ,X2 = 32.30, P 〈 0. 05 ）. （2）The positive rate of Livin expression in the gastric cancer tissues was higher than that in the normal tissues （73.58 vs 14%,X2 = 36.96,P 〈 0.05 ）. （3）The expression of FAF1 was signifi- cantly related with the histological differentiation （ P 〈 0.05 ）, while the expression of Livin was significantly correlated to the tumor diameter, infiltration degree, differentiation degree, lymph node metastasis and TNM staging （ P 〈 0. 05 ）. （4）There was no correlation be- tween the expression of FAF1 and Livin （ rs = 0. 307,P 〉 0. 05 ）. Conclusion Lack of FAF1 expression may play an important role in the occurrence and development of gastric cancer and inhibit the cancer cell differentiation. The Livin protein abnormal expression may be associated with the occurrence, development, invasion and metastasis of gastric cancer. The combined detection of FAF1 and Livin proteins provides an important basis for early diagnosis and inference of the evolution of gastric cancer.