民间药随手香的急性毒性及抗炎镇痛作用研究

目的:研究川产民间药随手香的急性毒性及部分药效作用。方法:采用急性毒性试验考查随手香的急性毒性;采用二甲苯致小鼠耳廓肿胀、醋酸致小鼠扭体反应实验,研究随手香的抗炎与镇痛作用。结果:通过急性毒性试验表明随手香无明显的急性毒性,安全性较好;二甲苯致小鼠耳廓急性炎症实验表明,随手香具有较好的抗炎作用;醋酸致小鼠扭体反应实验表明,随手香具有较好的镇痛作用。结论:初步判定川产民间药随手香急性毒性小,安全性较好,且具有抗炎、镇痛的作用,与民间用法相符。

Acute Toxicity and Anti-inflammatory, Abirritation Effects on Sichuan Folk Medicine Acorus Gramineus Soland

Objective： To research the acute toxicity and the anti-inflammatory, abirritation effects of Sichuan folk medicine Acorm gramineus Soland. Methods： The acute toxicity tests check with Acorus graminegs Soland of acute toxicity. Mouse auricular in- ttrrnesce model induced by dimethylbenzene, and acetic acid writhing was used in the anti-inflammatory and analgesic effects of Acorus gram/he,as Soland. Results： Through the acute toxicity tests show that Acorus gramineus Soland has no obvious acute toxicity, security is better. Ami-inflammatory effect was found in Acorus gramineus Soland through the auricular intumesce experiment. Acorus gramineus Soland had abirritation effect in the acetic acid writhing experiment. Conclusion： The preliminary judgement of Siehuan folk medicine Acorus gramineus Soland is the smaller acute toxicity and security is better. Acorus gramineus Soland has anti-inflammatory and analge- sic effects, it＇s agree with the folk usage.