| 当归治疗大鼠放射性肺损伤的实验研究 |
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| 引用本文： | 王小博.当归治疗大鼠放射性肺损伤的实验研究[J].中国交通医学杂志,2011,25(1):24-27. |
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| 作者姓名： | 王小博 |
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| 作者单位： | 南通市第一人民医院放疗科,江苏,226001 |
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| 摘 要： | 目的:观察当归对大鼠放射性肺损伤的治疗作用及对相关氧化指标的影响。方法:大鼠行直线加速器照射建立放射性肺损伤模型,以中药当归和地塞米松腹腔内注射,对大鼠肺组织作病理检查,检测肺组织中超氧化物歧化酶(SOD)、过氧化脂质(MDA)及羟脯氨酸(HP)含量的变化。结果:当归组肺组织急性炎症明显轻于单纯照射组;45d和60d局灶性纤维化不明显。肺组织SOD活性当归组照射后明显高于单纯照射组(P<0.01)。肺组织MDA含量照射后当归组明显低于单纯照射组(P<0.01)。肺组织HP含量照射后45d、60d单纯照射组、地塞米松组高于当归组(P<0.05)。结论:当归可提高SOD活性,减轻氧自由基损伤,抑制胶原沉积,保护肺组织,对放射性肺损伤有治疗作用。
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| 关 键 词： | 放射性肺损伤 当归 超氧化物歧化酶 丙二醛 羟脯氨酸 |
Experimental research of Chinese Angelica in rats with radiation-induced lung injury |
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| WANG Xiaobo.Experimental research of Chinese Angelica in rats with radiation-induced lung injury[J].Chinese Medical JOurnal of Communications,2011,25(1):24-27. |
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| Authors: | WANG Xiaobo |
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| Institution: | WANG Xiaobo(Department of Radiotherapy,the First Hospital of Nantong,Jiangsu226001) |
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| Abstract: | Objective:To study the effects and mechanism of Chinese Angelica against radiation-induced lung injury in rats.Methods:Rats in Groups A,B and C were exposed to 6 Mv X-rays at a dose of 20 Gy thoracically.The rats in Groups B and C were treated with angelica and dexamethasone respectively by gastrogavage one time a day just after X-ray exposure.The rats were sacrificed at day 5,15,30,45 and 60 after X-ray exposure.Pathological observation was performed after the lung tissues were treated with HE and Masson s... |
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| Keywords: | Radiation-induced lung injury Chinese Angelica Superoxidedismutase malondialdehyde hydroxyproline |
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