动脉瘤性蛛网膜下腔出血后脑血管痉挛与脑脊液IL-6的关系

目的:探讨动脉瘤性急性蛛网膜下腔出血(SAH)后脑脊液IL-6水平与血管痉挛的关系。方法 :经数字减影血管造影确诊为急性动脉瘤性SAH患者19例,入院后在24小时内经血管内介入治疗。术后第1、2、3、5、7天于同一时间点留取脑脊液,使用ELISA法测定IL-6的含量。将出现血管痉挛者设为观察组,无血管痉挛者设为对照组,对两组数据进行比较分析。结果:全组发生血管痉挛10例(52.6%),发生时间平均为手术后4.38天。脑血管痉挛发生率男性显著高于女性,差异有统计学意义(P<0.05)。观察组脑脊液中IL-6的平均值在术后第2、3、5、7天均显著高于对照组(P<0.05)。改良Fisher分级3级以上患者血管痉挛发生率也显著高于其他分级(P<0.05)。结论:血管痉挛者脑脊液中IL-6术后第2天升高,早于临床诊断时间,IL-6是预测SAH脑血管痉挛的参考指标。

Cerebral vasospasm after subarachnoid hemorrhage and IL-6 of cerebrospinal fluid

Objective: To evaluate the correlation between IL-6 of cerebrospinal fluid(CSF) and cerebral vasospasm(CVS) after subarachnoid hemorrhage(SAH).Methods: 19 patients which were diagnosed as SAH by digital subtraction angiography(DSA) were given endovascular treatment in 24 hours in hospital.10mL of CSF of every patient was tested with double antibody ELISA at the same time on 1,2,3,5,7 days after surgery.The patients were divided into two groups for clinical data analysis,the research group with CVS and the control group without CVS.Results: CVS developed in 52.6% of all the patients,with a mean onset of 4.38 days after surgery.Patients in the research group demonstrated statistically significant higher median values of IL-6CSF on days 2,3,5 and 7(P<0.05).On the other hand,gender and Fisher scale of CT taken first time after SAH were proved to be the correlation factor with CVS.Conclusion:IL-6CSF seems to be a reliable early biomarker for predicting CVS after SAH on Day 2 after treatment before clinical onset.