BCL-2蛋白在增生性肾炎与非增生性肾炎中表达及意义

目的：研究BCL-2蛋白在增生性肾炎与非增生性肾炎中表达程度及与蛋白尿、血尿之间的关系，探讨其与肾损害类型及预后的关系。方法：采用免疫组化-SP法检测肾活检标本中BCL-2蛋白的表达。结果：BCL-2蛋白在增生性肾炎26例中，着色强染21例(80.8%)，BCL-2蛋白表达程度与24h尿蛋白有正相关，与血尿无关。提示与疾病程度有关。非增生性肾炎14例着色低染11例（78.6％），BCL-2蛋白表达与24h尿蛋白无关，正常肾组织10例中着色低染8例（80.0％）.结论：BCL-2蛋白的表达可作为估计疾病程度和预后的指标之一，并为临床治疗提供依据。

STUDY ON THE SIGNIFICANCE AND EXPRESSION OF BCL-2 PROTEIN IN THE PROLIFERATIVE GLOMERULONEPHRITIS AND NON-PROLIFERATIVE GLOMERULONEPHRITIS

Objective:To investigate the expression of BCL- 2 protein in the proliferative glomerulonephritis and non-proliferative glomerulonephritis and to explore the relationship between the abnormal expression of them and proteinurine and hematuria.Method:We detected the show of BCL-2 protein with immunohistochemistry in tissue of renal biopsy.Proteinurine and hematuria have been tested.Results:The degree of expression of BCL-2 protein in 26 cases of the proliferative glomerulonephritis is strong frequence of strong staing is 80.8 percent cell.About 78.6 percent cell show low staing of BCL-2 protein. 80 percent cell show low staing of BCL-2 protein.There is a significance positive correlation of degree of expression of BCL-2 protein with quantity of 24 hours protein in 26 cases of the proliferative glomerulonephritis.There is no correlation between the degree of expression of BCL-2 protein and hematuria in 26 cases of the proliferative glomerulonephritis.There was no correlation between the degree of BCL-2 and quantity of 24 hours protein in 14 cases of non-proliferative glomerulonephritis.Conclusion:The expression of BCL-2 protein might be regarded as a marker of estimating degree of kidney damage and prognosis and to give a bases of clinic treatment.