乙肝病毒血清标志物与ALT相关性分析

目的:观察乙型肝炎表面抗原(HBsAg)阳性者乙肝病毒核心抗体IgM(HBc-IgM)及其他血清病毒标志物(HBsAb、HBcAb、HBeAg、HBeAb)不同阳性结果时血清丙氨酸氨基转移酶(ALT)的变化,分析其相关性。方法:检测1056例HBsAg阳性者血清病毒标志物和ALT,依据乙肝病毒标志物阳性情况的不同分为A、B、C、D共4组。计算各组ALT>40 U/L的例数及其百分率。结果:ALT异常增高的例数及其百分率分别为A组174例(76.7%),B组105例(55.3%),C组22例(21.4%),D组123例(23.2%),A、B组分别与C、D组间ALT异常增高率差异有统计学意义(P<0.05)。结论:在临床上同时检测抗HBc-IgM及各项血清学病毒标志物对了解乙型肝炎患者的病情和指导治疗具有较大的价值。

Analysis of relationship between hepatitis B core antibody IgM and ALT in serum

Objective:To observe the change of alanine aminotransferase(ALT)in hepatitis B surface antigen(HBsAg)posi- tive patients' serum with different positive groups of hepatitis B core antibody IgM(HBc-IgM)and other hepatitis B serologi- cal markers(HBsAb,HBcAb,HBeAg,HBeAb).Methods:Serum markers of vires and ALT from 1056 HBsAg positive pa- tients were detected by using enzyme-linked immunosorbent assay(ELSIA)and enzyme rate method.The 1056 cases were divided into 4 groups according to the positive situation of HBV serum markers,and then in each group the number and the percentage of ALT>40 U/L were counted.Results:The number and the percentage were as follows:174 cases(76.7%)in group A,105 cases(55.3%)in group B,22 cases(21.4%)in group C and 123 cases(23.2%)in group D.There was significant differ- ence of ALT abnormal increase rate between A,B groups and C,D groups separately(P<0.05),but there is no significant dif- ference between group C and D(P>0.05).Conclusion:The ALT increase rate of HBc-IgM positive serum from HBsAg posi- tive patients is more significant than that of HBc-IgM negative serum.