| 重症急性胰腺炎实验动物模型的快速制作和筛选 |
| |
| 引用本文： | 戴荣,许琳,陈梅树,徐江英,吴秀莲,王吉甫.重症急性胰腺炎实验动物模型的快速制作和筛选[J].南京军医学院学报,1994(4). |
| |
| 作者姓名： | 戴荣 许琳 陈梅树 徐江英 吴秀莲 王吉甫 |
| |
| 作者单位： | 海军医学高等专科学校外科教研室 南京210099(戴荣，许琳，陈梅树，徐江英，吴秀莲)，中山医科大学附属第一医院胃肠外科 广州510080(王吉甫) |
| |
| 摘 要： | 采用4种激活剂(去氧胆酸钠、牛胆盐、糜蛋白酶、胆汁加狗血)改良的Wakayama方法经杂交狗主胰管注入,制作重症急性胰腺炎实验动物模型.结果显示:用20mmol/L去氧胆酸钠10～15min即可诱导SAP,并可出现胰组织明显的病理学改变.更进一步的胰组织学检查表明,其病理征象与人的SAP相似.
|
| 关 键 词： | 胰腺炎 动物模型 去氧胆酸钠 病理改变 狗 |
Quick Manufacture and Screen in Dog of Experimental Animal Models of SAP |
| |
| Dai Rong,Xu Lin,Chen Meishu.Xu Jiangying,Wu Xiulian.Quick Manufacture and Screen in Dog of Experimental Animal Models of SAP[J].Journal of Nanjing Military Medical College,1994(4). |
| |
| Authors: | Dai Rong Xu Lin Chen MeishuXu Jiangying Wu Xiulian |
| |
| Abstract: | With improred wakayama method, the animal experimental models of SAP were manufactured by infusing four activators (sodium desoxycholate, bile, blood bile salt and chymotrypsin) into the major pancreatic duct of dog. The results showed that the models were induced by 20mmol/L sodium desoxycholate in 10 to 15 min,pathological changes were obvious in pancreatic tissues. Furthermore the pancreas was histologically examined,the his-tological singns of SAP were essentially similar to human's. |
| |
| Keywords: | pancreatitis animal model sodium desoxycholate pathological change dog |
| 本文献已被 CNKI 等数据库收录！ |
|
