| 树突状细胞肿瘤疫苗用于胃癌免疫治疗的新进展 |
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| 引用本文： | 宁敏曼,王立.树突状细胞肿瘤疫苗用于胃癌免疫治疗的新进展[J].医学综述,2006,12(4):200-202. |
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| 作者姓名： | 宁敏曼 王立 |
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| 作者单位： | 重庆医科大学附属第一医院消化内科,重庆,410006 |
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| 摘 要： | 树突状细胞(DCs)即是体内最有效的专业抗原提呈细胞,也是抗原特异性免疫应答的始动者,具有摄取、加工、递呈抗原至T淋巴细胞的能力,表达高水平的MHCⅠ、Ⅱ和CD80、CD86等共刺激分子,在免疫应答中起关键作用。以DCs为基础的各种疫苗在胃癌免疫治疗中取得了很大的成就。
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| 关 键 词： | 胃肿瘤 树突状细胞 免疫治疗 |
| 文章编号： | 1006-2084（2006）04-0200-03 |
| 收稿时间： | 2005-07-13 |
| 修稿时间： | 2005-12-04 |
The Progress about Immunotherapy of Gastric Carcinoma Using Dendritic Cell Tumor Vaccines |
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| NING Min-man,WANG Li.The Progress about Immunotherapy of Gastric Carcinoma Using Dendritic Cell Tumor Vaccines[J].Medical Recapitulate,2006,12(4):200-202. |
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| Authors: | NING Min-man WANG Li |
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| Institution: | The Department of Digestive Disease of the First Affiliated Hospital of Chongqing Medical University, Chongqing 410006, China |
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| Abstract: | Dendritic cells are not only the most effective and professional antigen-presenting cells,but also the initiator of antigen-specific immune responses.They can capture,process and present antigens to T lymphocyte and highly express MHC-Ⅰ,MHC-Ⅱ and many other costimulatory molecules such as CD_(80)、CD_(86) and so on.Dendritic cells play a key role in immune responses.Moreover,various vaccines based on DC-achieved a significant success in gastric cancer immunotherapy. |
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| Keywords: | Stomach neoplasms Dendritic cells Immunotherapy |
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