首页 | 本学科首页   官方微博 | 高级检索  
检索        

葡萄糖转运蛋白2与糖尿病的关系研究进展
引用本文:黄林晶,杨立勇.葡萄糖转运蛋白2与糖尿病的关系研究进展[J].医学综述,2009,15(23):3617-3619.
作者姓名:黄林晶  杨立勇
作者单位:福建医科大学附属第一医院内分泌科,福州,350005
摘    要:葡萄糖转运蛋白2(GLUT2)是胰岛β细胞的主要葡萄糖载体,在胰岛β细胞分泌胰岛素的过程中有重要的作用。GLUT2和葡萄糖激酶被认为是胰岛β细胞内的葡萄糖传感器,从而使体内胰岛素分泌反应的强度受血中葡萄糖浓度的调节。本文从GLUT2分子结构与功能、表达调控、与葡萄糖激酶关系、与糖脂毒性的关系和在糖尿病中的作用5个方面加以阐述。

关 键 词:葡萄糖转运蛋2  β细胞  胰岛素  葡萄糖激酶  糖尿病

Research Progress on the Relationship between Glucose Transporter 2 and Diabetes
Institution:HUANG Lin- jing, YANG Li-yong. ( Department of Endocrinology, the First Hospital Affdiated to Fujian Medical University, F uzhou 350005, China)
Abstract:Glucose transporter 2 (GLUT2) is the main glucose transporter of pancreatic β-cell. It plays an important role in the process of insulin secretion of pancreatic β-cell. GLUT2 and glucokinase are considered to be the glucose sensor in the pancreatic β-cell,they are feedback regulators which make the intensity of insulin secretion in response to blood glucose concentrations. In order to describe the biological role of GLUT2 and the relationship of GLUT2 and diabetes, this article gives a brief review from five aspects:GLUT2 molecular structure and function, expression regulation, the relationship with glucokinase, the relationship with glucotoxicity and 1 ipotoxicity, as well as the role in diabetes.
Keywords:GLUT2  β cell  Insulin  Glucokinase  Diabetes
本文献已被 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号