骨形态发生蛋白7与前列腺癌骨转移的研究进展

骨转移是前列腺癌的晚期表现之一,而且绝大部分前列腺癌骨转移灶表现为成骨性病变。骨形态发生蛋白7是强力骨诱导因子,不仅可以诱导成骨细胞分化标志物,还可刺激软骨细胞标志物的表达。前列腺癌骨转移倾向的内在分子机制一直是人们研究的重点。目前人们所接受的是Paget提出的"种子与土壤"学说,越来越多的实验和临床研究结果显示骨形态发生蛋白7在前列腺癌骨转移过程中起着重要的作用。

Study Progress of bone Morphogenetic Protein 7 with Bone Metastasis of Prostate Cancer

Bone metastasis was a manifestation of advanced prostate cancer,and the majority of prostate cancer with bone metastases showed bone lesions.BMP-7 was a powerful bone-inducing factor,not only can induce osteoblastic differentiation markers,but also stimulate cartilage cell marker expression.Prostate cancer bone metastases tending to the intrinsic molecular mechanism has been the research focus.Paget′s theory "seed and soil" was accepted,more experimental and clinical studies showed that bone morphogenetic protein 7(BMP7)played an important role in prostate cancer bone metastasis.