| 基因治疗病毒载体的研究进展 |
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| 引用本文： | 王振发,王烈,卫立辛.基因治疗病毒载体的研究进展[J].医学综述,2007,13(7):490-492. |
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| 作者姓名： | 王振发 王烈 卫立辛 |
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| 作者单位： | 1. 福建医科大学福总临床医学院普通外科,福州,350025
2. 第二军医大学附属三院肿瘤免疫与基因治疗中心,上海,200438 |
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| 摘 要： | 基因转移载体是基因治疗的重要组成部分,包括病毒载体和非病毒载体。目前应用的病毒载体主要有逆转录病毒载体、腺病毒载体、腺病毒相关病毒、慢病毒载体、单纯疱疹病毒载体等。不同的病毒载体各有利弊。随着对病毒载体的不断改造完善,提高其基因转移效率和安全性,病毒载体将在基因治疗中继续发挥重要作用。
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| 关 键 词： | 基因治疗 病毒载体 逆转录病毒载体 |
| 文章编号： | 1006-2084（2007）07-0490-03 |
| 收稿时间： | 2006-09-06 |
| 修稿时间： | 2006-09-062007-02-26 |
Study Advancement of Viral Vector for Gene Therapy |
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| WANG Zhen-fa,WANG Lie,WEI Li-xin.Study Advancement of Viral Vector for Gene Therapy[J].Medical Recapitulate,2007,13(7):490-492. |
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| Authors: | WANG Zhen-fa WANG Lie WEI Li-xin |
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| Institution: | 1. Department of General Surgery, Fuzhong dinical college, Fujiang Medical University, Fuzhou 350025; 2. Therapeutic Centre of Tumor Immunity and Gene Therapy, The Third Hospital Affdiated to The second Military Medical University. Shanghai 200428, China |
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| Abstract: | Gene transfer vector is the important ingredient in gene therapy, which includes virus vector and nan-vires vector. At present, the mainly applied virus vectors are retroviral vector, adenovirus vector adenovirus-associated virus slow virus vector, herpes simplex virus vector and so on. Different viruses have their own advantages and disadvantages. With the increasing reform and consummation of virus vector, it can play its important role continuously in gene therapy by promoting its efficacy and safty in gene transfer. |
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| Keywords: | Gene therapy Viral vector Retrovirus vector |
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