心肌缺血/再灌注损伤保护作用机制的研究

心肌缺血的再灌注治疗一方面恢复了心肌的血供,另一方面可能加重缺血心肌的损伤。心肌缺血/再灌注损伤一直以来是心血管医疗工作者的焦点问题。在保证再灌注治疗的心肌保护作用不受影响的情况下,如何减少再灌注损伤,国内外研究者们历经了艰辛的探索,相继提出了心肌缺血预适应-心肌药物预适应-心肌缺血后适应-心肌药物后适应的概念。该文就当今这一研究新热点及其发生、发展过程和心肌保护作用机制等进行综述。

The Research about the Protection Mechanism of Myocardial Ischemia-Reperfusion Injury

Reperfusion therapy for myocardial ischemia has been shown to recover blood supply of the ischemic myocardium,but it may aggravate the injury of ischemic myocardium.The myocardial ischemia and reperfusion injury have long been concerned by cardiovascular health workers.On the premise that reperfusion therapy myocardial protection is not affected,how to reduce reperfusion injury has caused hard work of domestic and foreign researchers,who have put forward the concept of ischemic preconditioning-pharmacologic preconditioning-ischemic postconditioning-pharmacologic postconditioning in succession.Here is to make a review on the current hot research spot and its genesis,development process and myocardial protection mechanism.