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溃疡性结肠炎的药物治疗进展
引用本文:田士军.溃疡性结肠炎的药物治疗进展[J].医学综述,2009,15(17):2612-2615.
作者姓名:田士军
作者单位:天津市武清区人民医院内一科,天津,301700
摘    要:溃疡性结肠炎(UC)是一种病因病机尚不十分清楚的慢性非特异性肠道炎症性疾病。目前治疗UC的药物仍以氨基水杨酸类、皮质类固醇类为首选。免疫抑制剂如硫唑嘌呤、甲氨蝶呤、环孢素等多用于重症难治性UC,治疗上取得了较大的成效,但不良反应明显。运用各种生物制剂,如肿瘤坏死因子抗体、黏附分子抑制剂、细胞因子拮抗剂等对发病机制的主要环节予以阻断,是较为理想的方法。本文对UC的药物治疗现状进行综述。

关 键 词:溃疡性结肠炎  药物  治疗

Drug Treatment of Ulcerative Colitis
TIAN Shi-jun.Drug Treatment of Ulcerative Colitis[J].Medical Recapitulate,2009,15(17):2612-2615.
Authors:TIAN Shi-jun
Institution:TIAN Shi-jun. ( The First Department of Internal Medicine, Tianjin Wuqing District People's Hospital, Tianjin 301700, China )
Abstract:Ulcerative colitis (UC) is a chronic and non-special inflammatory bowel disease. The etiology isn't completely clear. At present, aminosalicylic acid corticosteroid was the first choice to treat UC. It has made great effect in treating severe refractory UC with immune depressant such as asathioprine,methotrexate and ciclosporin,but the adverse effect is obvious. And it is an ideal method to intercept the main link of pathogenesy by using various biologic agent such as antibody of tumor necrosis factor,adhesion molecule inhibitor, cell factor antagon. The paper reviewed the drug treatment situation of UC.
Keywords:Ulcerative colitis  Drug  Treatment
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