支气管哮喘动物模型的研究进展

建立支气管哮喘动物模型有助于对哮喘的研究。针对Th2型细胞驱动的变态反应动物模型研究较多,并已应用于相关药物的研究。对支气管哮喘动物模型有一定疗效的药物对人类患者疗效欠佳,这可能与选择实验的动物和诱导哮喘表型的方法有关。啮齿动物和豚鼠模型是最常使用的支气管哮喘动物模型。目前动物模型仍存在许多问题,如在免疫学和解剖学上动物与人类存在差异,大多数模型在致敏时需要佐剂,成年动物应用较多。因此,明确每种模型的相对优点和局限性十分必要。

Research Progress in Animal Model of Bronchial Asthma

Animal models of bronchial asthma are beneficial to the study of asthma.These models have highlighted the importance of T-helper type 2 driven allergic responses in the progression of asthma and have been useful in the identification of interrelated drugs.Many drugs that have been shown to have some efficacy in animal models of bronchial asthma have shown little clinical benefit in human asthmatics,which may be due to a number of factors including the species of animal chosen and the methods used to induce an asthmatic phenotype in animals.Rodents and guinea-pigs are the most popular bronchial asthma models.At present,there are a lot of problems in animal models of asthma,for example the difference in immunology and anatomy between these species and human,the requirement for adjuvant during sensitization in most models,adult animals as the primary disease model.Therefore understanding of the relative merits and limitations of each model is necessary.