| 胰腺星形细胞活化及信号转导 |
| |
| 引用本文： | 梁晓强,章学林,张静喆.胰腺星形细胞活化及信号转导[J].医学综述,2008,14(22):3364-3367. |
| |
| 作者姓名： | 梁晓强 章学林 张静喆 |
| |
| 作者单位： | 1. 上海中医药大学龙华医院中医外科研究所,上海,200032
2. 上海中医药大学龙华医院胆道外科,上海,200032 |
| |
| 基金项目： | 上海市学科科研项目，龙华医院自然科学基金，上海市科委资助项目，上海市科委科技计划 |
| |
| 摘 要： | 胰腺纤维化是慢性胰腺炎的主要病理学特征,而活化的胰腺星形细胞(PSC)是胰腺纤维化发生的始动细胞,也是纤维化过程中的主要效应细胞。国内外研究发现多种因素,如细胞因子(常见的有血小板衍化生长因子、转化生长因子β1、白细胞介素10)、激活蛋白、氧应激及细胞内压力等诸多因素,均可通过各自的作用来影响PSC的活性,最终通过丝裂原活化蛋白激酶途径、TGF-β/Smad信号转导蛋白、过氧化物酶体增殖物激活受体γ等细胞内信号调节PSC的活化、增殖及胰腺慢性炎症和纤维化形成过程。
|
| 关 键 词： | 胰腺星形细胞 活化 信号转导 胰腺纤维化 |
Pancreatic Stellate Cell Activation and Signal Transduction |
| |
| LIANG Xiao-qiang,ZHANG Xue-lin,ZHANG Jing-zhe.Pancreatic Stellate Cell Activation and Signal Transduction[J].Medical Recapitulate,2008,14(22):3364-3367. |
| |
| Authors: | LIANG Xiao-qiang ZHANG Xue-lin ZHANG Jing-zhe |
| |
| Institution: | LIANG Xiao-qiang1,ZHANG Xue-lin2,ZHANG Jing-zhe2.(1.Institute of Chinese Traditional Surgery,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,2.Department of Hepatobiliary Surgery,China) |
| |
| Abstract: | Chronic pancreatitis (CP) is characterized by progressive pancreatic fibrosis,and activated pancreatic stellate cells (PSCs) play an important role in pancreatic fibrosis and chronic inflammation.Many kinds of cytokines,such as Platelet derived growth factor,transforming growth factor beta1 and interleukin 10 and leukomonocyte and so on,activator proteins(AP),oxidative stress and externally applied pressure all can affect the activity of pancreatic stellate cells by respective effects,and then through diffe... |
| |
| Keywords: | Pancreatic stellate cells Activation Signal transduction Pancreatic fibrosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
