老年性脑白质疏松症与血管性认知功能障碍的相关性临床研究

目的探讨老年性脑白质疏松症(LA)与血管性认知功能障碍(VCI)的相关性。方法选取2009年1月至2011年2月黑龙江省医院收治的经CT、磁共振成像检测确诊的LA患者78例为研究对象,比较LA不同分级的老年患者中VCI的发生率;分别应用简易智能量表(MMSE)、Hachinski缺血指数量表和蒙特利尔认知评估量表(MoCA)对老年LA患者进行评分。结果 LA不同分级的老年患者VCI发生率比较差异有统计学意义(P<0.05);LA不同分级患者MMSE、Hachinski、MoCA量表评分比较差异有统计学意义(P<0.05);多因素分析结果显示:年龄是发生VCI的独立危险因素(P<0.05)。结论老年LA患者中发生VCI的概率很大,且随着疾病严重程度的加剧和患者年龄的增加,发病率呈上升趋势。

Clinical Study on the Correlation between Senile Leukoaraiosis and Vascular Cognitive Impairment

Objective To explore the correlation between leukoaraiosis （LA） and vascular cognitive impairment（VCI）. Methods A total of 78 LA patients diagnosed by CT, MRI admitted by Heiliangjiang Provincial Hospital during Jan. 2009 and Feb. 2011 were included in the study, senile VCI incidence of patients with different LA degrees were compared ; mini-mental state examination （ MMSE ）, Hachinski isehemia index scale and Montreal cognitive assessment（MoCA） scale were applied to score the senile LA patients. Results VCI incidences of senile patients with different LA levels had statistically significant difference（ P 〈 0.05 ） ; MMSE, Hachinski, MoCA scores of patients with different LA levels had statistically significant difference （P 〈 0.05 ） ;multiple factors analysis indicated that age was an independent risk factor of VCI（ P 〈0.05 ）. Conclusion The probability of VCI in senile LA patients is high,which increases along with the aggravation of the disease, showing an up-trend incidence.