妊娠糖尿病的研究进展

妊娠糖尿病的患病率和病死率逐年增加,严重影响母婴的健康,但其发病机制至今尚未明确。临床研究发现多种因素促成了妊娠糖尿病的发生,包括胰岛素抵抗、胰岛β细胞功能缺陷、妊娠激素、炎性因子和脂肪细胞因子、遗传等。尤其近年关于炎性因子和脂肪因子的大量研究,为妊娠糖尿病的发病机制及对妊娠糖尿病的筛查和诊断方法的归纳与早期发现妊娠糖尿病提供了有力的依据。

Study Progress of Gestational Diabetes Mellitus

The incidence and mortality of gestational diabetes mellitus(GDM)are ascending year by year,which seriously threatens the health of mother and infant,however,the pathogenesis of GDM is still unclear.Clinical studies have shown lots of factors are related to GDM including insulin resistance,functional defeats of islet β cell,gestation hormones,inflammatory factors,adipocytokines,and genetics factors etc.,especially that recent researches on inflammatory factors and adipocytokines have provided strong evidence for the mechanism of GDM.The summary of screening and diagnosis of GDM provides basis for the early detection of it.