| ATP敏感性钾通道在心肌缺血/再灌注损伤中的作用 |
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| 引用本文： | 李清,王国林.ATP敏感性钾通道在心肌缺血/再灌注损伤中的作用[J].医学综述,2012(24):4144-4147. |
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| 作者姓名： | 李清 王国林 |
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| 作者单位： | 天津医科大学总医院麻醉科 |
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| 摘 要： | 心肌缺血/再灌注损伤是缺血性心脏病以及心脏手术后心功能不全的主要病理基础。寻找有效的心肌保护措施减轻心肌缺血/再灌注损伤具有重要意义。各种心肌保护措施,如心脏停搏液、缺血预处理和缺血后处理等成为人们研究的热点。ATP敏感性钾通道在缺血/再灌注心肌损伤的心肌保护策略中发挥了重要作用,是心肌保护的重要作用机制。
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| 关 键 词： | 缺血/再灌注损伤 心肌保护 ATP敏感性钾通道 |
Roles of ATPV sensitive Potassium Channels against Myocardial Ischemia/Reperfusion Injury |
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| LI Qing,WANG Guo-lin.Roles of ATPV sensitive Potassium Channels against Myocardial Ischemia/Reperfusion Injury[J].Medical Recapitulate,2012(24):4144-4147. |
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| Authors: | LI Qing WANG Guo-lin |
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| Institution: | .(Anesthesiology Department,Tianjin Medical University General Hospital,Tianjin 300052,China) |
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| Abstract: | Ischemia/reperfusion injury is a major pathophysiologic mechanism leading to myocardial dysfunction after myocardial infarction or cardiac surgery.It is necessary to find effective methods to limit ischemia/reperfusion injury.Many effective methods,such as cardioplegia,ischemia preconditioning and ischemia postconditioning garners are drawing more and more attention.ATP-sensitive potassium channels play important roles in myocardial protection against ischemia/reperfusion injury,which are the important mechanisms for cardio-protection. |
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| Keywords: | Ischemia reperfusion injury Myocardial protection ATP-sensitive potassium channels |
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