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| IgA肾病发病机制研究进展 | |
| 引用本文： | 林建松,郑智勇,武一曼.IgA肾病发病机制研究进展[J].医学综述,2009,15(23):3608-3610. |
| 作者姓名： | 林建松 郑智勇 武一曼 |
| 作者单位： | 1. 福建中医学院现代医学部病理教研组,福州,350003;南京军区福州总医院病理科,福州,350025 2. 南京军区福州总医院病理科,福州,350025 3. 福建中医学院现代医学部病理教研组,福州,350003 |
| 摘 要： | IgA肾病(IgAN)是最常见的原发性肾小球肾炎,是引起终末期肾衰竭的重要原因之一。IgAN的发病机制很复杂,人们针对其做了很多研究,但结果尚不十分明了。本文主要从IgA结构异常与清除异常、IgAN与循环免疫复合物沉积、IgAN与病原体、IgAN与局部肾素-血管紧张素系统、IgAN与基因以及IgAN与遗传因素及肾移植等方面介绍IgAN发病机制的最新进展。 |
| 关 键 词： | IgA肾病 发病机制 IgA IgA1 |
Study Progress about the Pathogenesis of IgA Nephropathy |
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| Institution: | LIN Jian-song, ZHENG Zhi-yong , WU Yi-man. ( 1. Department of Combination of TCM with Western Medicine, Traditional Chinese Medical University, Fuzhou 350003, China; 2. Department of Pathology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China). |
| Abstract: | IgA nephropathy （IgAN）, which can develop into end-stage renal failure, is the most common primary glomerulonephritis worldwide. The pathogenesis of IgAN is very complex. Although a member of researches have been taken,the etiopathogenisis of IgAN is not yet clear. In this paper,the latest progress of IgAN pathogenesis will be introduced in terms of the structural abnormalities of IgA, abnormal IgA clearance, the deposition of circulating immune complex, the pathogens, the local rennin-angiotensin system, the gene, the genetic factors, and the kidney transplantation. |
| Keywords: | IgA IgA1 |
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