凝血和纤溶与缺血性心脏病的关系

纤维蛋白原为重要的凝血因子,越来越多的研究表明高纤维蛋白原水平导致高凝状态,诱发血管疾病造成缺血性损伤。纤溶酶原激活物抑制物1是血浆纤溶活性的主要决定因素。异常升高纤溶酶原激活物抑制物1阻碍纤维蛋白分解,从而增加血浆纤维蛋白原。高纤维蛋白原水平导致高凝状态促进血栓形成。纤溶酶原激活物抑制物参与多种代谢性疾病血栓前状态的形成,造成动脉血栓形成的危险性增加。纤溶酶原激活物抑制物1、纤维蛋白原不仅在冠心病的发病机制中发挥着重要作用,而且与冠心病患者的不良预后有关。

Correlation between Ischemic Heart Disease and Coagulation and Fibrinolysis

Fibrinogen are important clotting factors,more and more research shows that high fibrinogen level leads to high condensation state,induces vascular disease causing ischemic damage.The plasminogen activator inhibitor-1(PAI-1)is the main factor determining the plasma fibrinolytic activity.The elevated PAI-l impedes the decomposition of fibrin,and then results in the increased plasma fibrinogen.The high level of fibrinogen leads to the hypercoagulabale state and accelerates the thrombosis.PAI-1 is involved in the prethrombotic state formation of a variety of metabolic diseases,resulting in increased risk of arterial thrombosis.PAI-1 and fibrinogen not only play an important role in the pathogenensis of coronary heart disease,but is also related to the poor prognosis of the disease.