感染与胃肠功能障碍

各种因素如创伤应激、重症感染及休克等均可导致胃肠功能障碍,严重感染则是临床中常见的因素之一。细菌、内毒素通过增加肠上皮细胞凋亡、坏死,抑制肠道免疫功能,破坏肠屏障及其修复功能等使肠道通透性增加,肠源性细菌、毒素入血并转移至远隔器官,而最终出现多系统器官功能衰竭。

Infection and the Gastrointestinal Dysfunction

Various factors such as wound stress,severe infection and shock could lead to gastrointestinal dysfunction,and severe infection is quite common in clinic.Bacterium and endotoxin can inhibit the immune function of intestinal tract by increasing cell apoptosis and necrosis of intestinal epithelium.Damaging the intestinal barrier and reparation function of gut raises gut permeabaility,resulting in bacterical and endotoxin translation and aggravation of endotoxemia,and ultimately leading to multisystem and orga...