慢性阻塞性肺疾病稳定期患者系统性炎症与肺动脉高压关系的探讨

目的探讨慢性阻塞性肺疾病稳定期患者伴或不伴肺动脉高压与系统性炎症的关系。方法选择我院133例慢性阻塞性肺疾病稳定期患者,采用多普勒超声心动图测定安静状态下肺动脉收缩压(SPAP),依据SPAP将其分为:肺动脉高压组63例,无肺动脉高压组70例。测定患者循环血液中C反应蛋白(CRP)、纤维蛋白原(FIB)水平。对照组为同期健康体检者73例。结果三组患者FIB水平间差异无统计学意义。慢性阻塞性肺疾病的肺动脉高压组SPAP及CRP水平显著高于对照组及无肺动脉高压组(P<0.05),无肺动脉高压组与对照组相比差异均无统计学意义(P>0.05)。肺动脉高压组患者的CRP水平经对数转换后与肺动脉压力水平呈正相关(P<0.05)。结论伴肺动脉高压的稳定期慢性阻塞性肺疾病患者存在低度炎症,需要适度抗炎治疗。

Systemic Inflammation and Pulmonary Hypertension in Patients with COPD at Stable Stage

Objective To investigate the systemic inflammation reflected in stable COPD patients with or without pulmonary hypertension.Methods 133 patients from our hospital were divided into pulmonary hypertension group(63 cases)and non-pulmonary hypertension group(70 cases)after the pulmonary artery pressure were measured by echocardiography,accoding to systolic pulmonary artery pressure(SPAP)in quiet state.The levels of C-reactive protein(CRP)and fibrinogen(FIB)were assessed.The control group were 73 healthy people at the time.Results FIB level among the three groups had no statistically significant differences.In patients with pulmonary hypertension group,serum SPAP and CRP leves were significantly higher than in those patients without pulmonary hypertension group(P<0.05),while there was no significant difference between the non-pulmonary hypertension group and the control group(P>0.05).CRP level of the pulmonary hypertension group was positively related to the hypertension level after logarithmic transformation(P<0.05).Conclusion Weak systemic inflammation exists in the stable COPD patients with pulmonary hypertension,proper anti-inflammation treatment is needed.