肿瘤标志物对原发性肝癌的诊断意义

原发性肝癌（PHC）是常见的恶性肿瘤之一，早期不易发现，晚期的治疗效果较差，病死率很高。因此，早发现、早诊断、早治疗就成为延长患者生存期、降低病死率的关键。甲胎蛋白（AFP）是诊断PHC公认的肿瘤标志物，但存在较高的假阴性，为弥补其实验室诊断的不足、提高PHC的检出率，高尔基体蛋白73、DLC-1基因、α—L-岩藻糖苷酶、米托蒽醌抗性基因、磷脂酰肌醇蛋白多糖3和转化生长因子β1等特异性、敏感性更高的肿瘤标志物已逐渐被应用于临床。

Research Progress in Diagnostic Role of Tumor Markers for Hepatocellular Carcinoma

Primary hepatocellular carcinoma（PHC） is one of the common malignant tumors that usually cannot he detected at early stage, and treatment effect in the advanced stage is unsatisfactory, and the mortality is high. Therefore, early detection, early diagnosis, early treatment are the key to prolong survival period and decrease the mortality. AFP is a well recognized tumor marker for PHC diagnosis,though there is a high false negative rate. In order to make up for the lack of laboratory diagnosis, and improve the detection rates of PHC,the more specific sensitive tumor markers such as Golgi protein 73, DLC-1 gene,cc-L-fucosidase, mitox- antrone resistance gene, phosphatidylinositol proteoglycan-3 and transforming growth factor-β1 have gradually been applied to clinical.