| NLRP3的炎性反应在2型糖尿病中的作用 |
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| 引用本文： | 钮忆欣.NLRP3的炎性反应在2型糖尿病中的作用[J].医学综述,2011,17(2):278-281. |
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| 作者姓名： | 钮忆欣 |
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| 作者单位： | 上海交通大学,上海,200092 |
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| 摘 要： | 白细胞介素1β(IL-1β)、活性氧和硫氧还原蛋白相互作用蛋白(TXNIP)都与2型糖尿病的发病机制有关.其中IL-1β的产生及其在慢性高血糖时胰岛功能障碍中的发病机制尤为重要.为了使2型糖尿病患者中IL-1β、活性氧、TXNIP完全不同的驱动机制成为一个统一的模式,NLRP3的炎性反应起了核心作用,所以NLRP3炎性...
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| 关 键 词： | 白细胞介素1β 活性氧 硫氧还原蛋白相互作用蛋白 NLRP3炎性反应 2型糖尿病 |
The Role of NLRP3 Inflammasome in Type 2 Diabetes Mellitus |
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| NIU Yi-xin.The Role of NLRP3 Inflammasome in Type 2 Diabetes Mellitus[J].Medical Recapitulate,2011,17(2):278-281. |
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| Authors: | NIU Yi-xin |
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| Institution: | NIU Yi-xin1,SU Qing2.(1.Shanghai Jiaotong University,Shanghai 200092,China,2.Department of Endocrinology,Xinhua Hospital,School of Medicine,Shanghai Jiaotong University,China) |
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| Abstract: | Interleukin-1β(IL-1β),reactive oxygen species(ROS),and thioredoxin-interacting protein(TXNIP)are all implicated in the pathogenesis of type 2 diabetes mellitus(T2DM).The production of IL-1β plays a critical role in the islet dysfunction in the context of chronic hyperglycemia.NLRP3 inflammasome is essential for the integration of IL-1β,ROS,and TXNIP in the pathogenesis of T2DM.Therefore,NLRP3 is thought to contribute greatly to the occurrence of T2DM. |
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| Keywords: | Interleukin-1β Reactive oxygen species Thioredoxin-interacting protein NLRP3 inflammasome Type 2 diabetes mellitus |
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