铅对骨骼的损伤机制及其生物学标志物

环境中各种铅的化合物被机体吸收后,可以在细胞和分子水平影响骨骼系统的功能,主要有调节血液中激素的水平,干扰骨细胞对激素的调节能力;直接影响成骨细胞的功能;通过氧化应激损伤骨骼系统中的细胞或大分子活性蛋白;影响钙信使系统,导致骨细胞生理调节功能损伤。因此,骨骼中铅的水平较血液中铅的水平更能反映慢性铅中毒对机体的损害程度。

Injury Mechanisms and Biomarkers of Lead Toxicity to Bone

When lead compounds in the environment are absorbed into human body,they can affect bone function at the cellular and molecular levels.Lead mainly regulates blood hormones and disrupts the response of bone cells to hormones.Lead directly impairs the function of bone cells and damages skeletal cells and active macromolecules via oxidative stress.The compromise of calcium messenger system can also interfere with the physiological regulation of bone cells.Therefore,the level of bone lead rather than that of se...