晚发性抑郁认知功能的研究进展

老年抑郁症常存在广泛的认知功能损害,较早发性抑郁患者,晚发性抑郁具备独特的临床特点,遗传倾向较早年发病者低,发病机制至今尚不明确。近年来研究表明,晚发性抑郁患者多伴有明显的认知功能障碍,发生痴呆的风险增高。现就晚发性抑郁的认知功能损害在神经心理学、神经影像学以及治疗转归方面进行综述。

Research Progress of Cognitive Dysfunction in Late-onset Depression

Older adults with depression often present with signs and symptoms indicative of functional or cognitive impairment,which is of unique clinical features compared to earty-onset depression.Genetic factors are generally thought to be of less significance in late-onset depressed patients than the early-onset.Late-onset depression is more frequently associated with cognitive dysfunction,which may be an increasing risk of dementia.Here is to make a review on late-onset depression with cognitive dysfunction from the perspectives of neuropsychological,neuroimaging,treatment response and prognostic factors.