阻塞性睡眠呼吸暂停综合征和缺血性脑卒中的炎性反应

阻塞性睡眠呼吸暂停综合征(OSAS)患者易发生缺血性脑卒中,并使其预后加重。诸多实验证实了OSAS存在增高的炎性细胞因子水平,脑缺血后再灌注过程中亦有炎性细胞聚集增加及细胞因子表达上调,OSAS特征性的慢性间断性缺氧,类似于缺血再灌注损伤,导致激活炎症通路超过了自适应途径,激活核因子κB及其调控编码基因表达前炎性因子产物,导致血管内皮功能障碍、动脉粥样硬化,从而诱发及加重了缺血性脑卒中。

Inflammatory Reaction in Obstructive Sleep Apnea Syndrome and Ischemic Stroke

Patients with obstructive sleep apnea syndrome(OSAS)are prone to suffer ischemic stroke and with bad prognosis.A number of experiments confirmed that levels of inflammatory factors are elevated in OSAS.Cerebral ischemia and reperfusion is also accompanied by accumulation of inflammatory cells and cytokines.The unique form of hypoxia occurring in OSAS,similar to ischemia and reperfusion,can lead to a selective inflammatory pathways,activate NF-κB and control the expression of genes including those encoding inflammatory cytokines and cell receptors,thus,mediate the endothelial dysfunction and atherosclerosis,then induce the ischemic stroke.