| RNA干扰——一种有力的基因沉默工具 |
| |
| 引用本文： | 彭辉兵,全智华.RNA干扰——一种有力的基因沉默工具[J].医学综述,2007,13(3):177-180. |
| |
| 作者姓名： | 彭辉兵 全智华 |
| |
| 作者单位： | 南华大学附属第一医院心血管内科,湖南,衡阳,421001 |
| |
| 摘 要： | RNA干扰(RNAi)自从1998年被阐明以来,一直是科学研究的一大热点。短短几年,基于此机制建立的技术,在功能基因组学、微生物学、基因表达调控机制研究等领域得到了广泛应用,已经成为一种有力的基因沉默方法。尤其对非编码RNA中的短干扰RNA与微小RNA的研究日益受到重视。本文从RNAi技术的发展、作用机制及应用等方面进行综述。
|
| 关 键 词： | RNA干扰 双链RNA 短干扰RNA 微小RNA 基因沉默 |
| 文章编号： | 1006-2084（2007）03-0177-04 |
| 收稿时间： | 2006-06-13 |
| 修稿时间： | 2007-01-05 |
RNAi——a Powerful Tool for Gene Silencing |
| |
| PENG Hui-bing,QUAN Zhi-hua.RNAi——a Powerful Tool for Gene Silencing[J].Medical Recapitulate,2007,13(3):177-180. |
| |
| Authors: | PENG Hui-bing QUAN Zhi-hua |
| |
| Institution: | Department of Cardiovascular Medicine, The First Affiliated Hospital of Nan Hua University, Hengyang 421001, China |
| |
| Abstract: | The RNA interference has been being a hot spot in study since it is elucidated in 1998.Although few years passed,many methods based on this has been widely used in functional genome,microbiology and regulatory mechanism of gene expression,which has been a strong method in gene silencing,among which especially small interfering RNA and microRNA pointing to noncoding RNA is attracting more attention.This article reviews RNAi in its development,mechanism of action and application. |
| |
| Keywords: | RNA interference Double strand RNA Small interfering RNA MicroRNA Gene silencing |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
